Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here for more information on The Virtual Advisor

Sign In to gain access to subscriptions and/or personal tools.
Autism
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Park, R. J.
Right arrow Articles by Bolton, P. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Park, R. J.
Right arrow Articles by Bolton, P. F.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Pervasive Developmental Disorder and Obstetric Complications in Children and Adolescents with Tuberous Sclerosis

Rebecca J. Park

University of Cambridge, UK rjp42{at}cam.ac.uk

Patrick F. Bolton

University of Cambridge, UK

Children with autism have an increased risk for obstetric complications but it is not known whether these are of primary aetiological significance. It is also unclear whether obstetric complications play a secondary role in shaping phenotypic expression in individuals at genetic risk for autism. We investigated this question by studying the role of obstetric complications in determining phenotypic manifestations in tuberous sclerosis, a single gene disorder frequently associated with autism spectrum disorders. Obstetric histories of 43 children with non-familial TS and 40 unaffected siblings were obtained using a structured parent interview. ADI-R, ADOS-G and IQ evaluations were undertaken. Children with TS experienced more obstetric complications than their unaffected siblings, but these were related to mild rather than severe adversities. No differences in obstetric complications were found in children with and without autism spectrum disorders and there was no positive correlation between obstetric adversities and severity of autism spectrum disorders or intellectual impairments.

Key Words: cognitive development • obstetric complications • pervasive developmental disorder • tuberous sclerosis

Autism, Vol. 5, No. 3, 237-248 (2001)
DOI: 10.1177/1362361301005003002
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Br. J. PsychiatryHome page
H. Gardener, D. Spiegelman, and S. L. Buka
Prenatal risk factors for autism: comprehensive meta-analysis
The British Journal of Psychiatry, July 1, 2009; 195(1): 7 - 14.
[Abstract] [Full Text] [PDF]

Home page
 J Child NeurolHome page
M. Wiznitzer
Autism and Tuberous Sclerosis
J Child Neurol, September 1, 2004; 19(9): 675 - 679.
[Abstract] [PDF]