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Urinary Peptides in Rett Syndrome

K. M. Solaas

Institute of Pediatric Research, The National Hospital, University of Oslo, Norway

O. Skjeldal

Child Neurology Section, Pediatric Clinic, The National Hospital, University of Oslo, Norway

M. L. G. Gardner

School of Biomedical Sciences, University of Bradford, UK

B. F. Kase

Institute of Pediatric Research, The National Hospital, University of Oslo, Norway

K. L. Reichelt

Institute of Pediatric Research, The National Hospital, University of Oslo, Norway, k.l.reichelt{at}Klinmed.uio.no

Rett syndrome is a neuro-developmental disorder related to autistic behavior. Persons with autism have previously been found to have hyperpeptiduria. We here report a significantly higher level of peptides in the first fasting morning urine from 53 girls with Rett syndrome (both classical and congenital) compared with 53 healthy girls. This elevation in urinary peptides was similar to that in 35 girls with infantile autism. As in persons with autism, the individual levels of urinary peptides in the Rett syndrome group varied, and about a fifth were within the normal range. Levels of peptides were lower in girls with classic Rett syndrome than in girls with congenital Rett syndrome. This may be due to different etiological causes or to active and stagnant phases of the disease. Urine from girls with Rett syndrome was found to have higher frequency and higher levels of some urinary peptides that may cause inhibition of brain maturation and epilepsy.

Key Words: opioids • peptides • Rett syndrome • urine

Autism, Vol. 6, No. 3, 315-329 (2002)
DOI: 10.1177/1362361302006003008
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K. L. Reichelt and O. Skjeldal
IgA antibodies in Rett syndrome
Autism, March 1, 2006; 10(2): 189 - 197.
[Abstract] [PDF]